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RNA

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Rapid, Single-Tube Method for Quantitative Preparation and Analysis of RNA and DNA in Samples as Small as One Cell: This paper introduces a novel and highly reliable single-tube method for rapid cell lysis, followed by quantitative preparation and analysis of both RNA and/or DNA molecules in small samples. In contrast to previous approaches, this procedure allows all steps to be carried out by sequential dilution in a single tube,...; Tags: Biotechnology, BioMed Central, RNA, molecule, DNA, analysis; White papers 2005-01-13
DNA-Free RNA Preparations From Mycobacteria: To understand mycobacterial pathogenesis analysis of gene expression by quantification of RNA levels becomes increasingly important. However, current preparation methods yield mycobacterial RNA that is contaminated with chromosomal DNA. After sonication of RNA samples from Mycobacterium smegmatis genomic DNA is efficiently removed by DNaseI in contrast to untreated samples. This...; Tags: Biotechnology, BioMed Central, RNA, DNA, analysis; White papers 2004-11-30
RNA Interference: Learning Gene Knock-Down From Cell Physiology: Over the past decade RNA interference RNAi has emerged as a natural mechanism for silencing gene expression. This ancient cellular antiviral response can be exploited to allow specific inhibition of the function of any chosen target gene. RNAi is proving to be an invaluable research tool, allowing much more rapid...; Tags: Biotechnology, BioMed Central, gene, RNA, biology, tool; White papers 2004-11-22
Co-Transcriptional Folding Is Encoded Within RNA Genes: The main aim of this work is to study if and how co-transcriptional folding is encoded within the primary and secondary structure of RNA genes. In order to achieve this, the paper presents the known primary and secondary structures of a comprehensive data set of 361 RNA genes as well...; Tags: Biotechnology, BioMed Central, RNA, gene; White papers 2004-08-05
In Vitro Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells in a Photo Polymerizing Hydrogel: Mesenchymal stem cells MSCs from skeletally mature goats were encapsulated in a photopolymerizing polyethylene glycol-based hydrogel and cultured with or without transforming growth factor b1 TGF to study the potential for chondrogenesis in a hydrogel scaffold system amenable to minimally invasive implantation. Chondrogenic differentiation was evaluated by histological, biochemical, and...; Tags: Biotechnology, RNA, photograph; White papers 2003-09-25

Additional Resources

Boehringer Ingelheim licenses drug targets from autoimmune collaboration with Galapagos: Mechelen, Belgium; 17 July 2008 - Galapagos NV (Euronext: GLPG)announced today that Boehringer Ingelheim has exercised its right tolicense two drug targets from the autoimmune research agreement withGalapagos' BioFocus DPI service division, resulting in a milestonepayment to Galapagos. This...; Articles 2008-07-17
Scientists Report Most Comprehensive View of Mammalian Transcriptome: Applied Biosystems SOLiD[TM] System Used to Survey RNA Landscape of Mouse Stem Cells; Study Expected to Help Scientists Better Understand Genetic Basis of Complex Diseases FOSTER CITY, Calif. -- Scientists from the University of Queensland, Australia and Applied Biosystems Inc. (NYSE:ABI) have teamed together to conduct the most...; Articles 2008-07-16
Caliper Life Sciences Introduces LabChip GX and GXII Microfluidic Instruments to Address Specific Needs of Proteomic and Genomic Researchers: - New Systems Provide Advanced DNA, RNA, and Protein Separation Capabilities - HOPKINTON, Mass., July 15 /PRNewswire-FirstCall/ -- Caliper Life Sciences, Inc. today introduced two microfluidics-based separations products, the LabChipR GX and LabChip GXII benchtop systems, for fast, automated, 1-D electrophoretic separations of protein, DNA, and...; Articles 2008-07-15
NYISO Issues 2008 Comprehensive Reliability Plan: Market-based solutions address reliability of New York's bulk electricity grid through 2017 RENSSELAER, N.Y. -- The Board of Directors of the New York Independent System Operator NYISO has approved the 2008 Comprehensive Reliability Plan CRP for New York's bulk electricity grid. According to the plan, proposed market-based solutions,...; Articles 2008-07-15
Dicerna Pharmaceuticals, a Second Generation RNA Interference Company, Completes Second Closing of Series A Financing; Unveils Strategic Focus: - Company Adds New Investor Abingworth - CAMBRIDGE, Mass. -- Dicerna Pharmaceuticals, Inc. (www.dicerna.com), an RNA interference company developing novel therapeutics utilizing proprietary Dicer Substrate Technology[TM], today announced a second closing of its Series A financing, receiving a total of $8.4 million in additional venture capital from new...; Articles 2008-07-15
Silence Therapeutics Announces Successful Opposition of Glover Patent: LONDON, July 11 /PRNewswire/ -- Silence Therapeutics plc (London AIM: SLN), a leading European RNA interference RNAi focused biotechnology company, announced today the successful opposition of a fundamental Alnylam Pharmaceuticals, Inc. European patent resulting in the patent being revoked in its entirety. The Opposition Division of the...; Articles 2008-07-11
Probes and Tags to Study Biomolecular Function: for Proteins, RNA, and Membranes - Out Now: DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/research/3826d4/probes_and_tags_to) has announced the addition of the "Probes and Tags to Study Biomolecular Function: for Proteins, RNA, and Membranes" report to their offering. The only resource to systematically review current experimental methods, this handy reference enables researchers to select the best solution...; Articles 2008-07-09
Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain: Study Demonstrates Differentiation of Primary Tumors From Metastases in the Brain With Accuracy Near 90% Identifying Whether a Brain Malignancy is a Primary Tumor or a Metastasis is a Recurring Challenge for Pathologists Using Current Technologies Accurately Differentiating Primary From Metastatic Tumors is Critical for Optimal...; Articles 2008-07-09
Rosetta Genomics to Present at Collins Stewart Fourth Annual Growth Conference: REHOVOT, Israel and JERSEY CITY, New Jersey, July 3 /PRNewswire-FirstCall/ -- Rosetta Genomics Ltd , a leading developer of microRNA-based diagnostics and therapeutics, announced today it will present Collins Stewart Fourth Annual Growth Conference on Wednesday, July 9, at 8:30 am EST at the Mandarin Oriental Hotel in New...; Articles 2008-07-03
Senesco Chooses VGXI to Produce Factor 5A Plasmid: NEW BRUNSWICK, N.J., July 3 /PRNewswire-FirstCall/ -- Senesco Technologies, Inc. ("Senesco" or the "Company") announced today that it has contracted with VGXI, Inc. (The Woodlands, TX) ("VGXI") to supply the plasmid portion of the Company's combination therapy consisting of the Factor 5A gene and siRNA against Factor 5A....; Articles 2008-07-03
Senesco Signs a Supply Agreement for Polyplus-transfection's Delivery System: NEW BRUNSWICK, N.J., July 3 /PRNewswire-FirstCall/ -- Senesco Technologies, Inc. ("Senesco" or the "Company") announced today that it has contracted with Polyplus-transfection (Illkirch, France) to supply Polyplus's "in vivo-jetPEI" for systemic delivery of Senesco's combination therapy of siRNA against Factor 5A and a plasmid of the Factor 5A...; Articles 2008-07-03
DiagnoCure's GCC marker for the staging of colorectal cancer discussed at the Eastern Cooperative Oncology Group: QUEBEC CITY, July 2 /PRNewswire-FirstCall/ -- DiagnoCure Inc. (TSX: CUR), a life sciences company commercializing high-value cancer diagnostic tests and delivering laboratory services, announced today that Dr. Timothy J. Holzer, Vice President, R&D and Production at DiagnoCure, and Dr. Scott Waldman, from Thomas Jefferson University, were speakers on June...; Articles 2008-07-02
Poly(ester amine)-mediated, Aerosol-delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis: Rationale: The low efficiency of conventional therapies in achieving long-term survival of patients with lung cancer calls for the development of novel therapeutic options. Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. Objectives: To demonstrate...; Articles 2008-07-01
Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension: Rationale: Platelet-derived growth factor PDGF promotes the proliferation and migration of pulmonary artery smooth muscle cells PASMCs, and may play a role in the progression of pulmonary arterial hypertension PAH, a condition characterized by proliferation of PASMCs resulting in the obstruction of small pulmonary arteries. Objectives: To analyze the...; Articles 2008-07-01
Lung Inflammation Induced by Lipoteichoic Acid or Lipopolysaccharide in Humans: Rationale: Recognition of pathogen-associated molecular patterns by Toll-like receptors TLRs is considered to be important for an appropriate immune response against pathogens that enter the lower airways. Objectives: We studied the effects of two different TLR agonists relevant for respiratory infections in the human lung: lipoteichoic acid (LTA; TLR2...; Articles 2008-07-01

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