BNET Industries
Market Cap:$10.8M
- Public
- US
Dow Jones Description
Alfacell Corporation is the first company to advance a biopharmaceutical product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCONASE, is an RNase that overcomes the challenges of targeting RNA for therapeutic purposes while enabling the development of a new class of targeted therapies for cancer and other life-threatening diseases. In addition to an ongoing Phase IIIb study in malignant mesothelioma, Alfacell is conducting a Phase I/II trial of ONCONASE in non-small cell lung cancer (NSCLC) and other solid tumors. ONCONASE is a first-in-class therapeutic based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells while sparing normal cells. ONCONASE triggers apoptosis, the natural death of cells, via multiple molecular mechanisms of action. Alfacell's proprietary drug discovery program is also the basis for the development of recombinant designed RNases for chemical conjugation and fusion (gene and protein) products with various targeting moieties, such as monoclonal antibodies, growth factors, and cytokines. This program also provides for joint design and development of new products with outside partners seeking line-extensions and/or improvements of the therapeutic effectiveness of their existing products. ...
President, CFO & COO
Charles MunizNumber of Employees 15
Peer Companies
NAICS Code Biological Product (except Diagnostic) Manufacturing: 325414
News & Analysis
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Alfacell Corporation F3Q08 (Qtr End 04/30/2008) Earnings Call Transcript
Question-and-Answer Session Operator Operator Instructions Your first question comes from Stephen Dunn - Dawson James. Stephen Dunn - Dawson James Do you have your results of 122 patients? Do you have a hypothesis of the mechanism of actions for ONCONASE and why it would work...
Alfacell Corp. F2Q08 (Qtr End 1/31/08) Earnings Call Transcript
Question-and-Answer SessionOperator Operator Instructions Our first question comes from the line of Raymond Myers with Emerging Growth Equities. Please go ahead. Raymond Myers - Emerging Growth Equities Thank you and good morning. Tina Shogen Good morning. Raymond Myers - Emerging Growth Equities Good morning, Tina. Let see, well, thank...
Alfacell F1Q08 (Qtr End 10/31/07) Earnings Call Transcript
Question-and-Answer Session Operator Operator Instructions Our first question comes from the line of Stephen Dunn with Dawson James. Please proceed with your question. Stephen Dunn - Dawson James Securities Good morning, Tina and Larry. Thanks for taking my call. Just a couple of questions here; you’ve got additional...
Alfacell F4Q07 (Qtr End 7/31/07) Earnings Call Transcript
Question-and-Answer Session Operator Operator Instructions Our first question is coming from Raymond Myers of Emerging Growth Equities. Raymond A. Myers - Emerging Growth Equities Thank you for taking the questions and congratulations, Tina and Larry, for getting to this point. We are almost to the un-blinding of our...
Alfacell Corporation Receives Progressive Following.
M2 PRESSWIRE-14 December 2006-www.streetinvesting.com: Alfacell Corporation Receives Progressive FollowingC1994-2006 M2 COMMUNICATIONS LTD RDATE:14122006 Streetinvesting.com is the author of this release. This release is a result of our current concentration on Alfacell Corporation (NASDAQ:ACEL) and their latest corporate developments and market...
Phase III Results: ONCONASE Vs. doxorubicin Presented At ASCO Meeting; ONCONASE shows Survival Benefit in Patients with Malignant Mesothelioma
Business Editors and Health/Medical Writers BLOOMFIELD, N.J.--BUSINESS WIRE--May 23, 2000 Alfacell Corporation (OTCBB:ACEL) announced today that preliminary survival results of our Phase III trial were presented at the 90th annual meeting of the American Society of Clinical Oncology ASCO in New Orleans, LA by Nicholas Vogelzang, M.D., Fred...
Tumoricidal and Radiosensitizing Effects of Onconase; Studies in Human Prostate Carcinoma, Lung Adenocarcinoma and Rat Hepatoma
BLOOMFIELD, N.J.--BUSINESS WIRE--Oct. 7, 1999-- Alfacell Corporation (OTC BB:ACEL). Independent in vivo studies showed that ONCONASER was significantly more effective than the control treatment in inhibiting tumor growth in transplanted human and murine tumor models. Furthermore, researchers measured changes in several important physiological parameters of tumors. ONCONASE significantly...
Chief Financial Officer Resigns
BLOOMFIELD, N.J.--BUSINESS WIRE--July 9, 1999-- Alfacell Corporation (OTCBB: ACEL) announced today the resignation of Gail Fraser, the Company's Chief Financial Officer. Ms. Fraser has also resigned from the Company's Board of Directors. Ms. Fraser indicated that she will pursue other business opportunities. Strategic and daily business operations will remain...
ALFACELL's Core Technology Receives International Recognition
BLOOMFIELD, N.J.--BUSINESS WIRE--May 19, 1999-- Alfacell and the NIH co-sponsor the 5th International Meeting on Ribonucleases ALFACELL Corporation (OTCBB: ACEL) announced today that scientists from 17 countries met at the Airlie Center in Warrenton, VA from May 12-16, 1999 to present their latest findings on the basic...
ALFACELL Corporation Announces Nasdaq Delisting
BLOOMFIELD, N.J.--BUSINESS WIRE--April 28, 1999-- ALFACELL Corporation (NASDAQ: ACEL) announced that the Nasdaq Stock Market Nasdaq notified the Company that its common stock would be delisted from the Nasdaq SmallCap Market effective at the close of business April 27, 1999 for failing to meet the minimum bid price requirements...
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Decision Makers
| Name (plus bio) | Position |
|---|---|
| Charles Muniz | President, CFO & COO |
| Andrew P Aromando | Chief Operating Officer |
| Diane Scudiery | Director, Clinical & Regulatory Operations |
| Dr Susanna Rybak | |
| Jacob V Maizel | |
| John J Costanzi | |
| Carter Stephen | Director |
| Stephen K. Carter | Director |
Board of Directors
| Name (plus bio) | Position |
|---|---|
| James J Loughlin | Chairman |
| Michele Carbone | Chairman |
| Donald R Conklin | Member, Board of Directors |
| Harvey I Pass | Board of Directors |
| John P Brancaccio | Board of Directors |
| Paul M Weiss | Board of Directors |
| Raja M Flores | Board of Directors |
| Zbigniew Darzynkiewicz | Board of Directors |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | President, CFO & COO | Current |
| Alfacell Corp | Board of Directors | Current |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Chief Operating Officer | Current |
| Onconase | Senior Vice President, Commercial Development and Operations | Current |
| Sandoz Pharmaceuticals | Sales Representative | Former |
| Innovex, Inc. | Senior Executive | Former |
| Quintiles Transnational Corp. | Senior Executive | Former |
| Rutgers University | M.A. | Former |
| The College of New Jersey | B.A. | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Director, Clinical & Regulatory Operations | Current |
| Onconase | Director, Clinical and Regulatory Operations | Current |
| Alfacell Corp | Board of Directors | Current |
| Enzon Pharmaceuticals, Inc. | Director of Clinical Research | Former |
| Fairleigh Dickinson University | M.A. | Former |
| Rutgers University | M.Ed. | Former |
| William Paterson University | B.A. | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Current | |
| Harvard Medical School | Assistant Professor of Pathology | Former |
| National Hockey League | Former | |
| NCI, Inc. | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Current | |
| NCI, Inc. | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Current | |
| Thompson Cancer Survival Center | Medical Director | Former |
| The University of Texas | Director of the Cancer Center | Former |
| University of Texas Medical Branch | professor of medicine | Former |
| Georgetown University School of Medicine | Residency | Former |
| Wilford Hall Medical Center | Former | |
| University of Texas Medical Branch | Director | Former |
| Georgetown University | M.D. | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Chairman | Current |
| KPMG International | Former | |
| Alfacell Corp | Director | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Chairman | Current |
Stephen K. Carter, M.D. has served on our Board of Directors since September 1998. Since 1997, Dr. Carter has been a consultant to the pharmaceutical industry. Dr. Carter was Senior Vice President of Research and Development at Boehringer Ingelheim Pharmaceuticals, Inc. from 1995 to 1997. Prior to joining Boehringer, Dr. Carter was Senior Vice President of Worldwide Clinical Research and Development at Bristol-Myers Squibb Company. From 1976 to 1982, Dr. Carter served as Director of the Northern California Cancer Program. Dr. Carter was also appointed to President Clinton's panel for AIDS drug development. Dr. Carter is a director of Allos Therapeutics, Alfacell Corporation, Emisphere Technologies, Inc. and Vion Pharmaceuticals Inc. and several privately held companies. Dr. Carter received an A.B. in History from Columbia College and an M.D. degree from New York Medical College. He completed a medical internship and residency at Lenox Hill Hospital.
| Organization | Position | Status |
|---|---|---|
| Emisphere Technologies, Inc. | Director | Current |
| Vion Pharmaceuticals, Inc. | Director | Current |
| Cytogen Corporation | Director | Current |
| Alfacell Corp | Director | Current |
| Allos Therapeutics, Inc. | Director | Current |
| Callisto Pharmaceuticals, Inc. | Director | Current |
| Tapestry Pharmaceuticals Inc. | Director | Current |
| Celator Pharmaceuticals | Director | Current |
| Bristol-Myers Squibb Company | Senior Vice President of Worldwide Clinical Research and Development | Former |
| New York Medical College | M.D. Degree | Former |
| Columbia College | A.B. In History | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Member, Board of Directors | Current |
| Bio Transplant Incorporated | Member, Board of Directors | Current |
| Cytotherapeutics, Inc. | Board of Directors | Current |
| Onconase | Board of Directors | Current |
| Vertex Pharmaceuticals Incorporated | Board of Directors | Current |
| inVentiv Health Inc. | Board of Directors | Current |
| Schering-Plough Corporation | Executive Vice President | Former |
| Schering-Plough Corporation | Senior Executive | Former |
| Schering-Plough Corporation | Chairman, Health Care Products Division | Former |
| Schering-Plough Healthcare Products Corp. | Chairman | Former |
| Rutgers University | MBA degree | Former |
| Williams College | B.A. | Former |
| Organization | Position | Status |
|---|---|---|
| New York University Medical Center | Chief of Thoracic Oncology | Current |
| New York University Medical Center | Director of the Division | Current |
| Asbestos Corporation Ltd. | Director of the Division of Thoracic Surgery | Current |
| Alfacell Corp | Board of Directors | Current |
| Rosetta Genomics Ltd. | Vice Chairman | Current |
| Onconase | Board of Directors | Current |
| Medical University of South Carolina | Chief | Former |
| University of Mississippi Medical Center | Chief Surgeon | Former |
| Wayne State University | Professor | Former |
| Duke University School of Medicine | Former | |
| The Johns Hopkins University | Former |
John P. Brancaccio, a retired CPA, has served as a Director of our company since April 2004. Since April 2004, Mr. Brancaccio has been the Chief Financial Officer of Accelerated Technologies, Inc., an incubator for medical device companies. From May 2002 until March 2004, Mr. Brancaccio was the Chief Financial Officer of Memory Pharmaceuticals Corp., a biotechnology company. From 2000 to 2002, Mr. Brancaccio was the Chief Financial Officer/Chief Operating Officer of Eline Group, an entertainment and media company. Mr. Brancaccio is currently a director of Alfacell Corporation as well as a director of each of Xenomics, Inc. and FermaVir Pharmaceuticals, Inc.
| Organization | Position | Status |
|---|---|---|
| Accelerated Technologies Corporation | Chief Financial Officer | Current |
| Xenomics, Inc. | Director | Current |
| Onconase | Board of Directors | Current |
| Fermavir Pharmaceuticals, Inc. | Director | Current |
| Alfacell Corp | Board of Directors | Current |
| Inhibitex, Inc. | Board of Directors | Current |
| Callisto Pharmaceuticals, Inc. | Board of Directors | Current |
| Compensation Committees | Board of Directors | Current |
| Pawfect Foods Inc | Board of Directors | Current |
| Memory Pharmaceuticals Corp. | Chief Financial Officer | Former |
| Memory Pharmaceuticals Corp. | Secretary and Treasurer | Former |
| Seton Hall University | Certified Public Accountant | Former |
| Deven International | Former | |
| Memory Pharmaceuticals Corp. | Treasurer | Former |
| Seton Hall University | Degree In Accounting | Former |
| Organization | Position | Status |
|---|---|---|
| Procertus Biopharm, Inc. | Acting President and CEO, Director | Current |
| Gala Biotech | President | Current |
| Venture Investors LLC | Managing Director | Current |
| Mithridion | Board of Directors | Current |
| Alfacell Corp | Board of Directors | Current |
| Caden Biosciences Inc. | Board of Directors | Current |
| Procertus Biopharm, Inc. | Board of Directors | Current |
| Cardinal Health, Inc. | President | Former |
| Wyeth Pharmaceuticals, Inc. | Director of Licensing | Former |
| Wyeth-Ayerst Laboratories | Director of Licensing | Former |
| Wyeth-Ayerst | Director of Licensing | Former |
| Venture Investors LLC | Analyst | Former |
| University of Wisconsin-Madison | M.B.A. | Former |
| Carleton University | Bachelor of Science In Biochemistry | Former |
| Organization | Position | Status |
|---|---|---|
| Alfacell Corp | Board of Directors | Current |
| Albert Einstein College | Former |
Stephen K. Carter, M.D., a Director of the Company since 2003, is the former Senior Vice President, Clinical and Regulatory Affairs, of Sugen, Inc. (ownership of Sugen has since passed to Pfizer, Inc. as part of its acquisition of Pharmacia in April 2003). Dr. Carter previously was the Senior Vice President, Research and Development of Boehringer Ingelheim Pharmaceuticals, Inc., now independently owned. Prior to this, he served 13 years at Bristol-Myers Squibb Co., including, as its Senior Vice President, Worldwide Clinical Research and Development. Dr. Carter is a former Deputy Director at the National Cancer Institute (NCI)'s Division of Cancer Treatment and is a member of the American Society of Clinical Oncology. He received his Medical Doctorate from New York Medical College. He is currently a member of the boards of directors of Alfacell Corporation, Achillion Pharmaceuticals, Inc., Cytogen Corporation, Sopherion Therapeutics, Inc., and Vion Pharmaceuticals, Inc.
| Organization | Position | Status |
|---|---|---|
| Emisphere Technologies, Inc. | Director of the Company | Current |
| Threshold Pharmaceuticals, Inc. | Current | |
| Callisto Ltd. | Current | |
| Sunesis Pharmaceuticals, Inc. | Current | |
| Anisfield-Wolf Book Awards | Current | |
| Onconase | Board of Directors | Current |
| Allos Therapeutics, Inc. | Director | Current |
| Society of Surgical Oncology | Board of Directors | Current |
| Amphora Discovery Corporation | Board of Directors | Current |
| Cytogen Corporation | Director | Current |
| American Association for Cancer Research, Inc. | Board of Directors | Current |
| The American Law Institute | Board of Directors | Current |
| Emisphere Technologies, Inc. | Board of Directors | Current |
| Aspen Institute | Board of Directors | Current |
| Tapestry Pharmaceuticals Inc. | Director | Current |
| Alfacell Corp | Director | Current |
| American Society of Clinical Oncology | Board of Directors | Current |
| The Celator | Board of Directors | Current |
| Celator Pharmaceuticals | Director | Current |
| American Association for Cancer Research, Inc. | Member | Current |
| The American Law Institute | Member | Current |
| Aspen Institute | Trustee | Current |
| Bristol-Myers Squibb Company | Senior Vice President, Worldwide Clinical Research and Development | Former |
| United States Court of Appeals for the District of Columbia Circuit | Clerk | Former |
| NCI, Inc. | Former | |
| New York Medical College | M.D. | Former |
| Vion Pharmaceuticals, Inc. | Board of Directors | Current |
| Columbia College | A.B. | Former |
| Stanford University | Bachelor's Degree | Former |
| Columbia University | B.A. | Former |
| Yale University | Degree | Former |
| New York Medical College | Degree | Former |
| Stanford University | member | Former |
Zbigniew Darzynkiewicz, M.D., Ph.D., is the Director of the Brander Cancer Research Institute at the New York Medical College and the Professor of Medicine and Pathology at the same College. Formerly, Dr. Darzynkiewicz was the Professor of Cell Biology and Genetics at Cornell University Medical School, a Member of the Sloan-Kettering Institute for Cancer Research, the Head of the Experimental Cell Research Laboratory, and the Director of the Flow Cytometry Core Facility Network, all at the Sloan-Kettering Institute, New York. Dr. Darzynkiewicz is the Editor of the Experimental Cell Research and Cell Proliferation and a Member of the Editorial Boards of nine other scientific journals. He is the past President of The Cell Kinetics Society and also past President of the International Society for Analytical Cytology (ISAC; with over 2,000 members from over 60 countries). Dr. Darzynkiewicz has authored 400 original publications and over 75 chapters and reviews in books devoted to the subject of cell growth, regulation of the cell cycle and apoptosis, and has authored and/or edited 11 books. He holds five US patents, several are pending. His publications have been cited over 9,000 times in the scientific literature. He consults several pharmaceutical companies and is on the Board of Scientific Advisors of the Alfacell Company (Bloomfield, NJ). Dr. Darzynkiewicz received his M.D. (with highest honors) in 1960 and his Ph.D. in 1966 from the Medical School of Warsaw, Warsaw, Poland. He completed his post-graduate studies at the State University of New York at Buffalo and the Medical Nobel Institute of Karolinska Institute, Stockholm, Sweden. Since 1974, he has been associated with the Sloan-Kettering Institute for Cancer Research, and since 1990, he has been with New York Medical College, Valhalla, New York.
| Organization | Position | Status |
|---|---|---|
| Pharmaseq, Inc. | Director of the Brander Cancer Research Institute | Current |
| Editorial, LLC | Board of Directors | Current |
| New York Medical College | Director | Current |
| Alfacell Corp | Board of Directors | Current |
| Weill Medical College of Cornell University | Professor of Cell Biology and Genetics | Former |
| National Aeronautics and Space Administration | Former | |
| New York Medical College | Ph.D | Former |
| State University of New York at Buffalo | Post - Graduate | Former |
| The State University of New York | post-graduate studies | Former |
| Karolinska Institute | Former |
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