An important feature of meconium-instilled newborn lungs is an inflammatory response and apoptotic cell death. Apoptosis exists also in healthy lungs, but in meconium-instilled lungs its level is usually dramatically higher. Apoptosis plays an important role in normal cell life, but increased levels of apoptosis induce great damage for any...
MOUNTAIN VIEW, Calif., Nov. 6 /PRNewswire/ -- Frost & Sullivan today announced that the 2008 European Technology Innovation of the Year Award in molecular/cellular imaging has been bestowed upon Aposense Ltd., for its pioneering molecular platform for the targeting and imaging of apoptosis. Israeli-based Aposense's technology platform,...
Phase 1 Study Results Published in Blood, Journal of the American Society of Hematology MALVERN, Pa. and MONTREAL, Quebec -- Gemin X, a clinical stage biopharmaceutical company developing novel, targeted cancer therapeutics, today announced that one of its lead oncology candidates, obatoclax, has demonstrated biological and anti-cancer activity...
MALVERN, Pa. & MONTREAL -- Gemin X, a clinical stage biopharmaceutical company developing novel, targeted cancer therapeutics, today announced that Glenn Gormley, M.D., Ph.D., president and chief executive officer of Gemin X, is scheduled to present at The 7th Annual BIO Investor Forum, being held October 29-31, 2008 at the...
Sederma recently launched a new hydrating ingredient, Aqualance, which contains an osmotic module to mimic estuary flora, and particularly that of the microalgae platymonas sub-cordiformis. In vitro studies showed that Aqualance improves the skin water holding capacity and provides the cells with a strong resistance to desiccation and both hypo-...
Learning is an active process emphasizing purposeful interaction and the use of knowledge in a meaningful environment. Scientific experiments are, by nature, inquiry-based activities; developing scientists must learn to propose hypotheses, design experiments, and select appropriate materials. Many cognitive psychologists have portrayed learning as a process of creating individual meaning...
Cactus Botanics has released Ceramide, from the family of lipid molecules concentrated in cell membranes that are comprised of sphinghosine and fatty acids. Supplementing with ceramide helps nourish the lipid bilayer of skin cells, keeping it pliant. Designed for use in the cosmeceuticals market, Ceramide has been found to activate...
Novel Pan Bcl-2 Inhibitor is a Potential Treatment for Broad Range of Cancers MALVERN, Pa. & MONTREAL -- Gemin X, a clinical stage biopharmaceutical company developing novel, targeted cancer therapeutics, today announced that the United States Patent & Trademark Office issued to Gemin X a patent protecting the...
Abstract Both epidemiological and experimental findings have indicated that components of Western diets influence colonic tumorigenesis. Among dietary constituents, calcium and cholecalciferol have emerged as promising chemopreventive agents. We have demonstrated that a Western-style diet WD with low levels of calcium and cholecalciferol and high levels of (n-6) PUFA, increased...
Abstract We examined the mechanisms by which daidzein inhibits the growth of breast cancer cells. First, we investigated its antiproliferative effects in MCF-7 and MDA-MB-453 cells exposed to 1-100 [micro]M daidzein for 24, 48, or 72 h. Daidzein significantly inhibited cell proliferation in a dose-and time-dependent manner (p...
The effects of acai polyphenolics on the antiproliferation and induction of apoptosis in HL-60 human leukemia cells were investigated. Interactions between anthocyanins and non-anthocyanin-polyphenolics in both their glycosidic and their aglycone forms were also investigated to determine additive or nonadditive responses. Polyphenolic fractions at 0.17-10.7 microM were found to reduce...
Oxidative stress induction triggers cancer cell death LEXINGTON, Mass. -- Synta Pharmaceuticals Corp., (NASDAQ: SNTA) today announced the publication of new findings in the American Association for Cancer Research journal, Molecular Cancer Therapeutics that describe the novel mechanism of action of elesclomol: driving programmed cell death apoptosis in...
PALO ALTO, Calif., Aug. 21 /PRNewswire-FirstCall/ -- Telik, Inc. announced today that its novel small molecule proteasome inhibitor program met a preclinical development milestone by demonstrating anticancer activity in preclinical models of human leukemia. The proteasome is an important cellular structure necessary for the growth and function of cancer...
U.S. researchers have identified 170 more proteins to add to the 91 already known to be associated with programmed cell death, or apoptosis. They also uncovered new information about how these proteins may function. The findings may help in the development of new drug treatments for stroke and...
NST NeuroSurvival Technologies Ltd.NST, the leading developer of agents that target apoptosis programmedcell death for both molecular imaging and therapy, today announced thecompletion of a $13.3 million financing. The company also announced thatit has changed its name to Aposense Ltd. In a two-part financing, Aposense Ltd. raised $6 million...
Abstract Vitamin A retinol and its analogs retinoids are important regulators of cell proliferation, differentiation, immune function, and apoptosis. The kidneys are target organs for vitamin A action. Retinoic acid RA, a vitamin A metabolite, is involved in embryonic kidney patterning through the control of receptor tyrosine kinase expression, which...
Cleveland BioLabs, Inc. (NASDAQ: CBLI)announced today that its first patent for Protectan CBLB502 was granted bythe Eurasian Patent Organization EAPO, which includes nine membercountries. This patent covers the method of protecting a mammal fromradiation using flagellin or its derivatives, including Protectan CBLB502. Cleveland BioLabs has filed over...
Abstract This study investigated the effects of a phytoestrogen-containing standardized soy extract SSE on the growth of nonsmall cell lung cancer (NSCLC; A549) xenografts in female athymic mice. Tumor-bearing mice received either sterile water or SSE [50 or 100 mg/(kg*d), per os], 5 d/wk, until the mean tumor weight in...
Skin cancers, i.e., basal cell carcinoma BCC, squamous cell carcinoma SCC and melanoma, belong to the most frequent tumors. Their formation is based on constitutional and/or inherited factors usually combined with environmental factors, mainly UV-irradiation through long term sun exposure. UV-light can randomly induce DNA damage in keratinocytes, but it...
In this report, we have examined the molecular basis of the photoprotective effect of a hydrophilic extract of the fern Polypodium leucotomos PL in vitro, using a solar simulator as the source of UV radiation SSR. We found that pretreatment of human keratinocytes with PL inhibited SSR-mediated increase of tumor...
Articles 2008-07-01
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