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- A Prospective Multi-Institutional Study of the Reproducibility of fMRI: A Preliminary Report From the biomedical Informatics Research Network
- Functional magnetic resonance imaging fMRI has significantly contributed to understanding both normal and diseased human brains. Variability often exists in the magnitude, spatial distribution, and statistical significance of the resulting fMRI maps due to differences in equipment and other site-specific differences. In addition, because of costly imaging, demanding tasks, and...
- White papers
- Portfolio Management Guides Product Development for biomedical Technology Leader
- A $300M developer of biomedical research technology was struggling to identify a long-term product road map that would raise company revenues to $1B. Building off the company's existing product development program, PRTM implemented a comprehensive portfolio management process for guiding decisions surrounding the company's five-year product road map. PRTM also...
- Case studies
- Agencourt Bioscience Corporation
- Agencourt Bioscience Corporation provides genomics services and nucleic acid purification reagents to biotech and pharmaceutical companies, academic institutions and government facilities. The discovery phase of drug development is costly and inefficient. Approximately one third of drugs fail during Phase I clinical trials and about 75 percent fail during clinical tests...
- Case studies
- Case History: Frisbie Memorial Hospital
- In 1993, like many health care facilities, Frisbie Memorial Hospital relied on one key biomedical staff member who could repair almost anything on-site. When she left, the administration knew it was time to re-evaluate the department. After reviewing insurance programs with national vendors, the Frisbie administrative team attended an impressive...
- Case studies
- Review of the Temporal and Geographical Distribution of Measles Virus Genotypes in the Prevaccine and Postvaccine Eras
- Molecular epidemiological investigation of measles outbreaks can document the interruption of endemic measles transmission and is useful for establishing and clarifying epidemiological links between cases in geographically distinct clusters. To determine the distribution of Measles Virus MV genotypes in the prevaccine and postvaccine eras, a literature search of biomedical databases,...
- White papers 2005-11-22
- Automatic Extraction of Candidate Nomenclature Terms Using the Doublet Method
- New terminology continuously enters the biomedical literature. How can curators identify new terms that can be added to existing nomenclatures? The most direct method, and one that has served well, involves reading the current literature. Present-day scholars are severely challenged by the enormous volume of biomedical literature. The purpose of...
- White papers 2005-10-18
- Distribution of Immunodeficiency Fact Files With Xml - From Web to WAP
- Although biomedical information is growing rapidly, it is difficult to find and retrieve validated data especially for rare hereditary diseases. This paper presents a new data model called fact file and an XML-based specification Inherited Disease Markup Language IDML, that were developed to facilitate disease information integration, storage and exchange....
- White papers 2005-06-26
- Application of Sophisticated Production Metrology and Nanometrology for Quality Control in Bio-Engineering
- Currently biomedical procedures are skill based to a wide extent and clinician's performance in this wide field of science is considerably variable. There are no scientific methods available to the biomedical and dental clinicians for measurement and feedback of the skill-based activities although some limited rules do exist to assist...
- White papers 2005-06-13
- Statistical Methods in biomedical Research and Measurement Science
- This paper concentrates on few statistical methods that are widely used in the analysis of clinical trials and clinical studies and are also used in theory of measurement science. Biostatistics is essentially statistics. It concerns the development of statistical methods and plays a key role in design and analysis of...
- White papers 2005-06-09
- Bioterrorism Countermeasure Development: Issues in Patents and Homeland Security
- This report explores the role of patents in encouraging the development and commercialization of new inventions and discusses the relationships between patent ownership and the generation of biomedical products. However, the grant of a patent on a pharmaceutical does not permit marketing of the product without the approval of the...
- White papers 2005-05-06
- Do biomedical Models of Illness Make for Good Healthcare Systems?
- Cultural and professional models of illness influence decisions on individual patients and delivery of health care. The biomedical model of illness, which has dominated health care for the past century, cannot fully explain many forms of illness. This failure stems partly from three assumptions: all illness has a single underlying...
- White papers 2004-12-01
- Working in a Virtual World - Medical Product Engineers Innovate , Cut Costs and Manage Risk
- Time-consuming and cost-prohibitive physical testing is often incapable of providing complete knowledge of product performance, e.g. how it works and responds in real-life applications. Engineers of such biomedical devices as implantable surgical devices, prostheses, orthopedics, dental implants, artificial limbs and organs have discovered virtual product development VPD processes and tools,...
- White papers 2004-09-17
- Doublet Method for Very Fast Autocoding
- Autocoding or automatic concept indexing occurs when a software program extracts terms contained within text and maps them to a standard list of concepts contained in a nomenclature. The purpose of autocoding is to provide a way of organizing large documents by the concepts represented in the text. Because textual...
- White papers 2004-09-15
- Sterilization of Medical Devices
- This paper focuses on different medical devices sterilization processes. Sterilization processes act on microorganisms in a chemical or physical way. The macromolecules of biomedical polymers can be attacked by the same mechanisms, and different forms of sterilization may result in hydrolysis, oxidation, softening, melting, chain scission, and depolymerization. Research has...
- White papers 2004-08-10
- Evolutionary biomedical Signal Processing Techniques
- Digital Signal Processing techniques constitute the basic scientific approach used in most of the current advances in medicine. In particular, the development of algorithms in order to extract, predict and model raw biomedical data series has revolutionized many routine, but data-intensive, areas of current medical practice. This paper presents an...
- White papers 2004-08-03
- biomedical Manufacturing in California
- California's biomedical industry provides highly skilled, high-wage jobs, and products ranging from genetically engineered human insulin to coronary stents?with high value for improving the lives of millions of people around the world. In the next decade, no industry holds greater economic potential. Even during the recent recession, when many California...
- White papers 2004-06-23
- Independent Component Analysis Applied in biomedical Signal Processing
- The EEG is composed of electrical potentials arising from several sources. Each source (including separate neural clusters, blink artifact, or pulse artifact) projects a unique topography onto the scalp-'scalp maps'. These maps are mixed according to the principle of linear superposition. Independent component analysis ICA attempts to reverse the superposition...
- White papers 2004-06-16
- The Economics of Innovation: Global Price Controls and the Future of biomedical R&D
- On February 19, 2004, The California Healthcare Institute CHI convened a group of distinguished leaders who influence healthcare policy across the spectrum of industry, government, and academia to discuss price regulation in the global context. The discussions specifically focused upon the cost of innovation in the field of drugs, devices...
- White papers 2004-05-07
- The biomedical Sectors in Australia and Canada: A Comparative Analysis
- This paper is one of a series of papers comparing the performance of the Australian and Canadian biomedical industries. It focuses on drug development alliances amongst biotech's and between biotech's and pharmaceutical companies and secondly, on technology transfer alliances between biotech's. The majority of alliances between biotech's are focused on...
- White papers 2004-05-01
- Two-Electrode Low Supply Voltage Electrocardiogram Signal Amplifier
- Portable biomedical instrumentation has become an important part of diagnostic and treatment instrumentation, including telemedicine applications. Low voltage and low-power design tendencies prevail. Modern battery cell voltages in the range of 3-3.6V require appropriate circuit solutions. A two-electrode biopotential amplifier design is presented, with a high common-mode rejection ratio CMRR,...
- White papers 2004-03-12
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