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Prolidase, a Potential Enzyme Target for Melanoma: Design of Proline-Containing Dipeptide-like Prodrugs
The analyses indicated that prolidase might be a desirable enzyme target based on its differential expression in melanoma cancer cell lines and its high substrate specificity for dipeptides containing proline at the carboxy terminus. The results suggest the possibility of targeting prolidase with prodrugs of anticancer agents for enhanced selectivity....
Brief Overview of BioMicroNano Technologies
This paper provides a brief overview of the fields of biological micro-electromechanical systems bioMEMs and associated nanobiotechnologies, collectively denoted as BioMicroNano. Although they are developing at a very rapid pace and still redefining themselves, several stabilized areas of research and development can be identified. Six major areas are delineated, and...
Some Items of Interest to Process R&D Chemists and Engineers
This white paper reports deals with some items of interest to process R&D chemists and engineers and further provides systematic and descriptive information about these items. They report how these various items can be prepared on multigram scale using chemical or enzymatic synthesis methodology. The paper explains each items with...
Process Development and Scale-Up of a Selective Alpha1-Adrenoceptor Antagonist
A synthetic route to a potent and selective r-1-adrenergic receptor antagonist has been developed and demonstrated in a pilot plant. The route has been used in two pilot plant campaigns and has produced RO3203546 in 2.3 and 12.0 kg batch sizes. The first pilot plant campaign focused primarily on the...
Modeling Hybridoma Cell Metabolism Using a Generic Genome-Scale Metabolic Model of Mus Musculus
The reconstructed cellular metabolic network of Mus musculus, based on annotated genomic data, pathway databases, and currently available biochemical and physiological information, is presented. Although incomplete, it represents the first attempt to collect and characterize the metabolic network of a mammalian cell on the basis of genomic data. The reaction...
Modeling the Morphology and Phase Stability of TiO2 Nanocrystals in Water
The potential of titanium dioxide nanoparticles for advanced photochemical applications has prompted a number of studies to analyze the size, phase, and morphology dependent properties. The paper work further reveals about titanium dioxide nanoparticles in water, to examine the effects of various adsorption configurations on the equilibrium shape and the...
Use of Operating Windows in the Assessment of Integrated Robotic Systems for the Measurement of Bioprocess Kinetics
This study examines the utility of an automated liquid handling robot integrated with a microwell plate reader to enable the rapid acquisition of bioprocess kinetic data. The relationship between the key parameters for liquid handling accuracy and precision and the sample detection period has been characterized for typical low and...
An Expeditious Scalable Synthesis of (S)-2-Amino-5-Methoxytetralin via Resolution
This report deals with process chemistry explored for developing practical preparation of (+/-)-2-amino- 5-methoxytetralin 1 and its resolution into S-11 via diastereomeric salt formation, which is being incorporated into N-0923 2,2 a potent dopamine D2 agonist that is now under clinical investigation as a therapeutic agent to treat Parkinson's disease...
Modeling and Simulation of the Swelling Behavior of pH-Stimulus-Responsive Hydrogels
The modulation of the swelling ability of the hydrogel matrix by pH-stimulus enables the dynamic control of the swelling forces, thereby obtaining effective diffusivity and permeability of the solutes, or mechanical energy from the hydrogel. In this work, a chemo-electro-mechanical model describing hydrogel behavior, based on multi-field effects, is developed...
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Letters to the Editor
Supply, demand Re: "As chemists gather, let's refocus efforts to gain diversity in science," Tuesday: Catherine T. Hunt, past president of the American Chemical Society, plays a familiar refrain. Her message is that we need more students especially women and minority students to take up science, technology, engineering, and mathematics...
Albemarle Scientists Named 'Heroes of Chemistry'
BATON ROUGE, La., Aug. 21 /PRNewswire-FirstCall/ -- Twelve scientists from specialty chemical maker Albemarle Corporation and ExxonMobil Research and Engineering Company were honored by the American Chemical Society ACS in a special ceremony Sunday night as "Heroes of Chemistry" for their work in the development of NEBULAR...
Spoonful of Sugar Really Might Help Medicine Go Down
If your child won't take medicine and shuns broccoli at the dinner table, his body may just be hard-wired to respond that way. "Kids reject the bad taste of medicine, because it's basic biology. Their system is designed to reject that taste, because many toxic substances are bitter and distasteful,"...
Calcium Might Have Taste Humans Can Detect
It may be time to add calcium to the types of tastes -- sweet, sour, salty, bitter and savory -- that can be detected by humans, according to U.S. researchers. They found that a taste for calcium exists in mice. Since mice and humans share many of the same genes,...
Modified MRI Spots Early Osteoarthritis
A modified form of MRI may help diagnosis osteoarthritis at an early stage when it may be possible to prevent or reduce permanent joint damage, say U.S. researchers. Current diagnostic methods don't detect osteoarthritis until it's in advanced stages. In this new approach, MRI is used to determine the concentration...
Scientists identify chemical odor of skin cancer: study
WASHINGTON AFP — US chemists have identified the odor that emanates from skin cancer, a development that researchers hope will advance diagnosis and treatment of the deadly disease, said a study out Wednesday. The creation of a "profile" of the chemical odors linked to skin cancer, may lead...
New, potentially damaging, pollutant is discovered
A previously unknown class of pollutants, formed in combustion ranging from cigarettes to power plants and diesel engines, was announced at the American Chemical Society's national meeting. Whether they are harmful to human health is unknown, although the chemist who discovered the particles said their existence might help explain why...
More Juices Found to Affect Drugs' Effectiveness: Study
Grapefruit juice, long known to boost the absorption of certain medications, isn't the only juice that doesn't mix well with drugs, according to the Canadian researcher who first identified the ill effects of grapefruit juice. Other common juices, including orange and apple, may limit the body's absorption of drugs, compromising...
The Merck Index Women in Chemistry Scholarships to be Presented at American Chemical Society National Meeting
WHITEHOUSE STATION, N.J. -- Merck & Co. Inc. today announced the winners of the second annual Merck Index Women in Chemistry Scholarship program. The program is designed to foster support for women choosing to pursue advanced degrees in medicinal or synthetic organic chemistry. "We are pleased to be...
A Hope: Contaminant-Free Synthetic Heparin
Robert J. Linhardt is a chemist with a dream: making the blood-thinner heparin by the bucketful without using animal tissue. pig intestines processed in China. That processing often is done in small mom-and-pop workshops, a situation conducive to contamination, said Linhardt, a professor of chemistry, biology and chemical engineering at...
DNA, Jim, but not as we know it: unnatural genetic letters build stronger double helix
If aliens have DNA, it might look something like this. Chemists have synthesized a DNA-like molecule using unnatural versions of the A, T, C and G "letters" that make up the genetic code. The resulting molecule has greater structural stability than natural DNA and would resist breakdown by...
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