Cellzdirect Inc.

Dr. Johanning received her M.S. and Ph.D. degrees in Biological Sciences from the University of Rhode Island. She moved to New Orleans where she did postdoctoral training in two Medical Centers. Karla did her first postdoctoral training in the Dept. of Biochemistry and Molecular Biology at Louisiana State University Medical Center where she studied the cellular and molecular biology of enzymatic processing of pro-hormones into bioactive peptides. Dr. Johanning then moved to Tulane University where she started her next postdoctoral position in molecular biology. As a Postdoctoral Fellow at the Tulane Cancer Center in the Medical School she did research on the effects of genetic and environmental factors on repetitive sequences resulting in genetic instability in the onset/progression of cancer. In March 2002 she joined the Center for Bioenvironmental Research at Tulane and Xavier Universities as the Sr. Research Scientist in the Environmental Endocrinology Lab. Karla conducted research in the field of "endocrine disrupters" applying her expertise in biomedical research as well as environmental, cellular and, molecular biology. At CellzDirect, Dr. Johanning serves as Study Director on drug metabolism projects including in vitro CYP450 inhibition and induction, metabolite stability and profiling, and enzyme identification studies.

Dr. Easterwood received her doctorate in chemistry from the University of Utah in Salt Lake City. Prior to joining CellzDirect, she completed her postdoctoral training in the Department of Pharmacology/Toxicology at the University of Utah. Her post-doctoral research under the leadership of Dr. Garold Yost focused on investigating the role of CYP450-dependent dehydrogenation in mechanism-based enzyme inhibition. Through these studies, Dr. Easterwood gained expertise in CYP450 enzyme kinetics and CYP450 inhibition (direct and time-dependent). In addition, her research focused on the identification of metabolites generated by CYP450-mediated catalysis of small molecules. At CellzDirect, Dr. Easterwood serves as Study Director on drug metabolism projects including in vitro CYP450 inhibition and induction, metabolite stability and profiling, and enzyme identification studies.

Dr. Ganesh Rajaraman is a study director for CellzDirecta s in vitro drug metabolism studies, including cytochrome P450 induction, inhibition, and druga "drug interaction studies. Dr. Rajaraman received his doctorate from the Faculty of Pharmacy, University of Manitoba under the guidance of Dr. Frank J. Burczynski. Dr. Rajaramana s dissertation focused on understanding the role of fatty-acid binding proteins in important hepatocellular processes such as fatty-acid uptake and transport, mitosis, and oxidative stress. As a Post-doctoral Research Fellow at the University of British Columbia, he conducted toxicological studies to assess the effect of herbal extracts on drug-induced hepatotoxicity in both in vivo animal models and in vitro rat hepatocyte models, under the guidance of Dr. Thomas K. Chang. Dr. Rajaraman gained expertise in the areas of in vitro hepatotoxicity screening, drug-induced liver toxicity, and drug-drug interactions involving cytochrome p450s through his graduate and post-doctoral training.

Senior Vice President/Corporate Operations and General Counsel of University Physicians Healthcare since May 2007; President of Aldrich Capital Company since January 2007; Chief Operating Officer of The Critical Path Institute from January 2006 to December 2006; General Partner of Valley Ventures, LP from September 2002 to December 2005; Managing Director and Founder of Tucson Ventures, LLC, from February 2000 to September 2002; Director of TEP and Millennium since 2000; Director of UES since 2004. Board member since 2000. Age 55.

Dr. Rob Taylor is study director for CellzDirecta s in vitro drug metabolism studies, including cytochrome P450 inhibition and induction, and drug drug interaction studies. Dr. Taylor received his doctorate from the Molecular Toxicology Interdepartmental Doctoral Program at the University of California at Los Angeles. Under the guidance of Dr. Oliver Hankinson, Dr. Taylora s dissertation focused on elucidating mechanisms of transcription of cytochromes P450, mediated by the aryl hydrocarbon receptor complex. Through his graduate training, Dr. Taylor gained expertise in molecular biology and cytochrome P450 gene induction by xenobiotics.