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- Groundbreaking Research Identifies Molecular Pathway Underlying Key Infection-Fighting Mechanism
- In this article researcher at the University of Massachusetts Medical School Worcester, Harvard University and Millennium Pharmaceuticals, Inc. reveals the discovery of a new pathway underlying the body's innate immune response, which provides immediate, first-line defense against organisms such as viruses. The research, published in the online edition of Nature...
- White papers
- The Expertise to Help You Build Your Practice: Molecular Imaging LifeNet
- MI LifeNet is part of Life, the unique customer care solution from Siemens that helps one to get the most from his or her investment. From the moment of purchase, Life surrounds the person with an array of programs and support that enables the continuous development of his or her...
- White papers 2006-08-01
- Molecular Magnetic Resonance Imaging
- Molecular MRI mMRI is a special implementation of molecular imaging for the noninvasive visualization of biological processes at the cellular and molecular level. More specifically, mMRI comprises the contrast agent-mediated alteration of tissue relaxation times for the detection and localization of molecular disease markers (such as cell surface receptors, enzymes,...
- White papers 2005-09-01
- Competence in Molecular Imaging
- In association with Ralph Weissleder's group at the Center for Molecular Imaging Research CMIR, Siemens Medical Solutions is developing the Molecular Imaging Portal MIPortal. This reliable, web-based software provides access to multimodality image data and nonimage data, like genomics. All data is organized in projects and experiments with secure access...
- White papers 2005-09-01
- Molecular Imaging Portal: New Development IT Platform for Imaging, Nonimaging and Genomics
- Modern imaging systems such as CT, SPECT, PET, MRI, ultrasound, and others generate a continuously growing amount of clinical and preclinical data every day - easily reaching terabytes in short time periods. In addition, the multiinstitutional and multidisciplinary nature of today's clinical research projects requires the creation of collaborative data...
- White papers 2005-09-01
- Molecular Imaging of Vulnerable Atherosclerotic Plaques
- Molecular imaging draws on expertise from many fields, ranging from basic physics or chemistry to clinical practice. The National Institutes of Health included molecular imaging as a part of the NIH Roadmap to Biomedical Research. There has been increased funding for molecular imaging research, resulting in exciting new developments representing...
- White papers 2005-09-01
- Molecular Imaging: A Triad of Technologies
- Until recently, many physicians solely associated molecular imaging with imaging technologies like PET, SPECT, ultrasound, or MRI. But to leaders in the field, it has come to mean much more. Today, molecular imaging is revolutionizing everything from drug discovery and preclinical studies of disease to clinical research and daily medical...
- White papers 2005-09-01
- Cellular and Molecular Imaging of Disease With Targeted Contrast Ultrasound Imaging
- Methods for molecular and cellular imaging with contrast-enhanced ultrasound have been developed that rely on the targeting of microbubbles or other acoustically active particles to disease-related molecules. These contrast agents are retained specifically in diseased tissue and can be imaged by high-sensitivity and high-resolution imaging algorithms currently available on the...
- White papers 2005-09-01
- Molecular Pain, a New Era of Pain Research and Medicine
- Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research. Molecular pain research addresses physiological and pathological pain at the cellular, sub cellular and molecular levels. These studies integrate pain research with molecular biology, genomics, proteomics, modern electrophysiology and neurobiology....
- White papers 2005-01-14
- Parameterization of Reversible Digitally Filtered Molecular Dynamics Simulations
- Reversible Digitally Filtered Molecular Dynamics RDFMD is a method of amplifying or suppressing motions in a molecular dynamics simulation, through the application of a digital filter to the simulation velocities. RDFMD and its derivatives have been previously used to promote conformational motions in liquid-phase butane, the Syrian hamster prion protein,...
- White papers 2004-12-17
- Superposition State Molecular Dynamics
- The ergodic sampling of rough energy landscapes is crucial for understanding phenomena like protein folding, peptide aggregation, polymer dynamics, and the glass transition. These rough energy landscapes are characterized by the presence of many local minima separated by high energy barriers, where Molecular Dynamics MD fails to satisfy ergodicity. To...
- White papers 2004-12-08
- In Situ Observation of Molecular Diffusion in Solid Supports Using Two-Photon Fluorescence Microscopy
- This paper demonstrates that two-photon fluorescence microscopy is a useful tool for monitoring the diffusion of molecules through polymeric solid supports. As a proof of principle, TentaGel beads were bound to a cover slip, and diffusion of Rhodamine 6G through single beads was observed in real time. Diffusion experiments performed...
- White papers 2004-11-18
- Utilization of Amylose-Lipid Complexes as Molecular Nanocapsules for Conjugated Linoleic Acid
- Amylose-conjugated linoleic acid CLA complexes were produced by water/dimethyl sulfoxide DMSO and KOH/HCl complexation methods. The formation of amylose V form was confirmed by X-ray diffraction XRD, and complexes formed at 30, 60, and 90 C exhibit melting temperatures exceeding 88 C. Atomic force microscopy AFM images showed distinct difference...
- White papers 2004-11-13
- Use of Block Hessians for the Optimization of Molecular Geometries
- The block Hessian matrix is constructed by mixing a small critical block of the accurate Hessian for key atoms involved in bond breaking and forming with large noncritical blocks of the lowlevel Hessian. The block Hessian strategy efficiently removed the pathological effects of using low-level Hessians, and therefore it provides...
- White papers 2004-11-02
- Molecular-Based Concepts in PV Towards Full Spectrum Utilization
- Molecular-based concepts offer the potential of low materials and processing costs in photovoltaics PV, which is especially interesting if high efficiencies can be obtained. To accomplish high efficiencies, a better utilization of the solar spectrum is of high importance. The concept of two-photon absorption in dye-sensitized solar cells and full...
- White papers 2004-02-16
- Characterization of the Metabolic Flux and Apoptotic Effects of OHydroxyl- and N-Acyl-modifed N-acetylmannosamine (ManNAc) Analogs in Jurkat (human T-lymphoma-derived) Cells
- This white paper discusses the results that provide fundamental insights into the role of sialic acid metabolism in apoptosis by demonstrating that ManNAc analogs can modulate apoptosis both indirectly via hydroxyl-group effects and directly through N-acyl-group effects. This work explore the structure-activity relationship of ManNAc analogs on cell viability and...
- White papers 2004-02-13
- Molecular Imaging - New Horizons for Radiology
- Advances in molecular biology and biochemistry have dramatically increased one's understanding of disease. The evolving perceptions that molecular mechanisms are the pathogenic basis of disease is changing modern medicine. New drugs often inhibit specific key pathways. In nuclear medicine, molecular imaging agents have been used for years, but most contrast...
- White papers 2003-11-22
- Molecular Electronics
- This paper provides description of a molecular-mechanical switch that forms the basis of a random access memory circuit, a molecular-based three-input mechanical Boolean sorter, a single-molecule electrically or magnetically gated switch, and a single-stranded DNA wire that is "turned on" by hybridization of the DNA into the double-stranded form. These...
- White papers 2003-05-01
- Molecular Modelling of Polyimide Membranes for Gas Separation
- Well-equilibrated molecular packing models have been produced for seven different polyimides. For all packings the transport properties solubility and diffusion coefficient have been calculated for nitrogen, oxygen and carbon dioxide using the Gusev-Suter method. Comparison with experimental data allowed validating the quality of the model structures. A significant improvement to...
- White papers 2002-02-15
- Molecular Electronics With Carbon Nanotubes
- Carbon nano-tubes have unique properties that make them a most promising system on which to base molecular electronics. The paper briefly reviews the electrical characteristics of carbon nano-tubes, and then focuses on carbon nano-tube field-effect transistors CNTFETs. Procedures by which hole-transport, electron-transport and ambipolar CNTFETs can be fabricated are presented,...
- White papers 2002-01-30
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